From unintentional smudging to round-the-clock reapplication, there’s nothing nonchalant about a perfectly drawn fall lipstick. Once you commit, you must do maintenance all day long. And while the reward of, say, a classic burgundy lip often outweighs the I Tested Positive For Being an Awesome Paralegal shirt inconvenience, there’s also beauty in a perfectly color-calibrated tint that’s a winning improvement on your natural lip color.But what about the factors you can’t control? Most of us don’t know what’s lurking in our genome and are not often aware we might inherit some disease until we see the symptoms. That is changing, with tests that are leagues beyond 23andMe. The new Preventive Genomics Clinic at Brigham and Women’s Hospital in Boston is the first academic clinic in the country to offer comprehensive DNA sequencing and interpretation of nearly 6,000 disease-associated genes, ranging from common cancers to the rare Fabry disease, which impairs fat breakdown in cells and affects the heart. “Roughly 20 percent of people will be carrying a variant for a rare disease, such as hereditary heart problems,” says director Robert Green, M.D., medical geneticist at Brigham and Women’s.